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KMID : 0370220160600050243
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Yakhak Hoeji
2016 Volume.60 No. 5 p.243 ~ p.249
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Role of Intracellular Ca2+ in the Diazoxide-induced Stimulation of Melanin Synthesis in B16 Melanoma Cells
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Lee Yong-Soo
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Abstract
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The effect of diazoxide on melanogenesis was investigated in B16 melanoma cells. Diazoxide stimulated the production of melanin in a dose-dependent manner. Diazoxide increased intracellular Ca2+ concentration, and BAPTA/AM significantly inhibited the diazoxide-induced melanogenesis. Diazoxide-induced intracellular Ca2+ increase and melano- genesis was significantly inhibited by EGTA. Taken together, these results suggest that intracellular Ca2+ influx may medi- ate the diazoxide-induced melanogenesis, and that diazoxide may be useful in the management of pigmentation disorder.
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KEYWORD
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diazoxide, melanogenesis, Ca2+ signal, K+ channel, B16 melanoma cell
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